Searchable abstracts of presentations at key conferences in endocrinology

ea0019p126 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Visfatin regulates insulin secretion and insulin receptor phosphorylation in a clonal beta-cell line

Brown J , Onyango D , Conner A , Ramanjaneya M , Dunmore S , Randeva H

Visfatin is a controversial molecule secreted from adipose tissue and known to be positively correlated with body mass. Previous reports have suggested that visfatin interacts with the insulin receptor signalling pathway. Due to its high expression in visceral fat tissue and its initial reported insulin sensitising effects it has been suggested to be involved in the pathogenesis of type 2 diabetes, although this link has yet to be well established. Since insulin receptors are ...